Template:Hormone levels in gonadally intact adolescent and adult females with complete androgen insensitivity syndrome
| Study | Location | n | Age (years) |
LH (IU/L) |
FSH (IU/L) |
T (ng/dL) |
DHT (ng/dL) |
E2 (pg/mL) |
P4 (ng/mL) |
SHBG (nmol/L) |
|---|---|---|---|---|---|---|---|---|---|---|
| Schindler (1975)[3] | Tübingen, DE | 4 | ? (17–22) | ?a | ?a | 1040 ± 300 | 79 ± 30 | 36.7 ± 7.1 | 0.06 ± 0.02 | ? |
| Blumenthal (1982)[4] | Johannesburg, ZA | 4 | 19 (18–28) | 70 (8–97) | 14 (6–22) | 1356 (1240–1577) | ? | 40 (26–79) | 0.96 (0.68–1.76) | ? |
| Melo (2003)[5] | Sao Paulo, BR | 8 | 16.5 (14–34) | 26 (14–43) | 7.4 (3.5–16) | 346 (173–1040) | ? | 30 (22–40) | ? | ? |
| Audi (2010)[6] | Barcelona, ES | 11 | 20 (13.5–40) | 10 (<0.1–35) | 2.3 (0.4–23.4) | 576 (144–1350) | ? | 33 (20–73) | ? | 52 (22–128) |
| Doehnert (2015)[7][8] | Lübeck, DE/Pisa, IT | 42 | 17.3 (14–50) | 18.5 (5.5–51.1) | 3.5 (0.4–16.3) | 576 (173–1450) | ? | 31 (5–70) | ? | 53 (15–99) |
| King (2017)[9] | London, UK | 31 | 19.7 (13.4–52.3) | 24.2 (13–59.1) | 4.6 (1.1–68.9) | 640 (233–1260) | ? | 35 (12–63) | ? | ? |
| Male ref. range | – | – | Adult | 1–10 | 1–7 | 346 (202–1010) | ? | 30 (10–50) | <0.6 | 10–50 |
| Female ref. range | – | – | Adult | 2–6.6 | 2–6.6 | 43 (20–86) | ? | 80 (10–395) | <3.2–25 | 30–90 |
| Abbreviations: LH = Luteinizing hormone. FSH = Follicle-stimulating hormone. T = Testosterone. DHT = Dihydrotestosterone. E2 = Estradiol. P4 = Progesterone. SHBG = Sex hormone-binding globulin. Notes: Values are mean (range) or mean ± standard deviation. Footnotes: a = LH = 73.2 ± 9.2 ng LER 907/mL, FSH = 40.2 ± 20.0 ng LER 907/mL. | ||||||||||
Template documentationReferences
- ^ Bertelloni S, Dati E, Baroncelli GI, Hiort O (2011). "Hormonal management of complete androgen insensitivity syndrome from adolescence onward". Horm Res Paediatr. 76 (6): 428–33. doi:10.1159/000334162. PMID 22156544.
- ^ Batista RL, Costa EMF, Rodrigues AS, Gomes NL, Faria JA, Nishi MY, Arnhold IJP, Domenice S, Mendonca BB (2018). "Androgen insensitivity syndrome: a review". Arch Endocrinol Metab. 62 (2): 227–235. doi:10.20945/2359-3997000000031. PMID 29768628.
- ^ Schindler AE, Freidrich E, Keller E, Joel EW, Jaeger-Whitegiver ER (November 1975). "In vivo und in vitro Untersuchungen bei Patienten mit testikulärer Feminisierung" [In-vivo and in-vitro studies of patients with testicular feminization]. Arch Gynakol (in German). 219 (1–4): 584. doi:10.1007/BF00669260. PMID 1243499.
- ^ Blumenthal NJ, Lubbe F, Harnekar AB, Adno A (November 1982). "Complete androgen insensitivity". S. Afr. Med. J. 62 (22): 812–4. PMID 7147110.
- ^ Melo KF, Mendonca BB, Billerbeck AE, Costa EM, Inácio M, Silva FA, Leal AM, Latronico AC, Arnhold IJ (July 2003). "Clinical, hormonal, behavioral, and genetic characteristics of androgen insensitivity syndrome in a Brazilian cohort: five novel mutations in the androgen receptor gene". J. Clin. Endocrinol. Metab. 88 (7): 3241–50. doi:10.1210/jc.2002-021658. PMID 12843171.
- ^ Audi L, Fernández-Cancio M, Carrascosa A, Andaluz P, Torán N, Piró C, Vilaró E, Vicens-Calvet E, Gussinyé M, Albisu MA, Yeste D, Clemente M, Hernández de la Calle I, Del Campo M, Vendrell T, Blanco A, Martínez-Mora J, Granada ML, Salinas I, Forn J, Calaf J, Angerri O, Martínez-Sopena MJ, Del Valle J, García E, Gracia-Bouthelier R, Lapunzina P, Mayayo E, Labarta JI, Lledó G, Sánchez Del Pozo J, Arroyo J, Pérez-Aytes A, Beneyto M, Segura A, Borrás V, Gabau E, Caimarí M, Rodríguez A, Martínez-Aedo MJ, Carrera M, Castaño L, Andrade M, Bermúdez de la Vega JA (April 2010). "Novel (60%) and recurrent (40%) androgen receptor gene mutations in a series of 59 patients with a 46,XY disorder of sex development". J. Clin. Endocrinol. Metab. 95 (4): 1876–88. doi:10.1210/jc.2009-2146. PMID 20150575.
- ^ Doehnert U, Bertelloni S, Werner R, Dati E, Hiort O (2015). "Characteristic features of reproductive hormone profiles in late adolescent and adult females with complete androgen insensitivity syndrome". Sex Dev. 9 (2): 69–74. doi:10.1159/000371464. PMID 25613104.
- ^ Doehnert U, Bertelloni S, Richter-Unruh A, Werner R, Hiort O (May 2011). Hormone profiles in adolescents and adults with complete androgen insensitivity syndrome. Proceedings of the 3rd International Symposium on Disorders of Sex Development.
- ^ King TF, Wat WZ, Creighton SM, Conway GS (August 2017). "Bone mineral density in complete androgen insensitivity syndrome and the timing of gonadectomy". Clin. Endocrinol. (Oxf). 87 (2): 136–140. doi:10.1111/cen.13368. PMID 28493277.